Perisynaptic GABA Receptors: The Overzealous Protector
نویسندگان
چکیده
منابع مشابه
Perisynaptic GABA Receptors The Overzealous Protector
An attempt to find pharmacological therapies to treat stroke patients and minimize the extent of cell death has seen the failure of dozens of clinical trials. As a result, stroke/cerebral ischemia is the leading cause of lasting adult disability. Stroke-induced cell death occurs due to an excess release of glutamate. As a consequence to this, a compensatory increased release of GABA occurs that...
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In cerebellar granule cells, delta subunit-containing GABA(A) receptors are found exclusively at extrasynaptic sites, but their subcellular distribution in other brain areas is poorly understood. We examined the anatomical localization and physiological activation of these receptors in adult mouse dentate gyrus granule cells. Immunocytochemistry revealed a high density of delta subunits in the ...
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Ian Martin is Professor of Pharmacology in the School of Life and Health Sciences at the University of Aston, Birmingham B4 7ET, UK. Susan Dunn is a Senior Lecturer in the Department of Pharmacology at the University of Bristol, University Walk, Bristol BS8 1TD, UK. They have common interests in GABAergic transmission in the central nervous system and their research is focused on the structure-...
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From an historical standpoint, the development of our understanding of basic mechanisms of the actions of gamma aminobutyric acid (GABA) and benzodiazepines began on separate paths. Classical pharmacology revealed similarity between the actions of GABA and benzodiazepines in the central nervous system. Furthermore, pharmacological experiments with selective agonists and antagonists indicated th...
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Microtubule-associated proteins (MAPs) have been identified as binding partners for ionotropic GABAA and GABAC receptors. These interactions suggest a potential role for MAPs in the cytoskeletal anchoring of receptor-ion channels at specific subcellular sites, such as synapses.
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ژورنال
عنوان ژورنال: Advances in Pharmacological Sciences
سال: 2012
ISSN: 1687-6334,1687-6342
DOI: 10.1155/2012/708428